牡蛎诺卡氏菌病

病原: Nocardia crassostreae

贝类宿主：太平洋牡蛎Crassostrea gigas/欧洲牡蛎Ostrea edulis

主要症状：引起牡蛎局部或全身疾病，受感染组织器官表面常可见直径约1cm的黄绿色脓疱突起，最后导致牡蛎大批死亡。组织病理观察显示病灶处革兰氏染色阳性、PAS染色阳性、单个呈分枝形、颗粒状嗜碱性的菌块，病灶四周被紧密聚集的血淋巴细胞环绕。

检测技术：引物PCR扩增，病灶组织脓疱压片观察

相关文献：

Engelsma MY, Roozenburg I, Joly J P. First isolation of Nocardia crassostreae from Pacific oyster Crassostrea gigas inEurope. Dis Aquat Organ,2008, 80(3):229-34.

Noèlia Carrascoa, Ineke Roozenburga, Michal Voorbergen-Laarman,et al. Development of a real-time PCR for detection of the oyster pathogen Nocardia crassostreae based on its homogeneous 16S-23S rRNA intergenic spacer region. Journal of Invertebrate Pathology, Available online 19 July 2013.